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Tramadol for postoperative shivering: a double-blind comparison with pethidine
S Bhatnagar1, A Saxena, T R Kannan
1Unit of Anesthesiology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansani Nagar, New Delhi.
Anaesthesia and Intensive Care
|April 21, 2001
Summary
Tramadol effectively treats postoperative shivering, offering a superior alternative to pethidine. This study found tramadol (1 mg/kg) significantly reduced shivering compared to pethidine (0.5 mg/kg) with no recurrence.
Area of Science:
- Anesthesiology
- Pharmacology
- Thermoregulation
Background:
- Post-anaesthetic shivering is commonly managed with non-pharmacological methods.
- Pharmacological interventions offer an effective alternative for controlling postoperative shivering.
- Tramadol's mechanism involves serotonin and norepinephrine reuptake inhibition, impacting thermoregulation.
Purpose of the Study:
- To compare the efficacy of tramadol versus pethidine in treating post-anaesthetic shivering.
- To evaluate the effectiveness of intravenous tramadol (1 mg/kg) against pethidine (0.5 mg/kg).
Main Methods:
- A randomized, double-blind trial involving 30 patients (ASA Grade 1 or 2).
- Patients received either tramadol 1 mg/kg or pethidine 0.5 mg/kg intravenously.
- Shivering grade, pulse, blood pressure, and respiratory rate were monitored for one hour post-injection.
Main Results:
- Shivering cessation was significantly higher in the tramadol group (12/15) compared to the pethidine group (4/15) at 10 minutes (P<0.05).
- Tramadol provided better sustained control of shivering.
- No recurrence of shivering was observed in patients treated with tramadol.
Conclusions:
- Intravenous tramadol at 1 mg/kg is more effective than pethidine at 0.5 mg/kg for treating postoperative shivering.
- Tramadol offers a more sustained and complete resolution of shivering.
- Tramadol presents a promising pharmacological option for managing post-anaesthetic shivering.