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Genes, environment and schizophrenia.

M T Tsuang¹, W S Stone, S V Faraone

¹Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA. ming.tsuang@hms.harvard.edu

The British Journal of Psychiatry. Supplement

|April 24, 2001

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Schizophrenia liability arises from both genetic and environmental factors, interacting within a neurodevelopmental framework. This multifactorial model, termed schizotaxia, aids in understanding and potentially preventing the disorder.

Area of Science:

Psychiatry
Genetics
Neuroscience

Background:

Family, twin, and adoption studies confirm a significant genetic contribution to schizophrenia.
Molecular genetic studies, despite replication challenges, have identified genes at various chromosomal locations.
Environmental factors play a crucial role, interacting with genetic predispositions to influence schizophrenia development.

Purpose of the Study:

To integrate genetic and environmental risk factors into a comprehensive neurodevelopmental model.
To conceptualize the underlying liability to schizophrenia.

Main Methods:

A review of relevant scientific literature was conducted.
Meehl's concept of 'schizotaxia' was reformulated to describe the disorder's liability.

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Main Results:

The reviewed literature supports a multifactorial etiology for schizophrenia liability.
Both genetic and environmental components are integral to this liability.

Conclusions:

Schizotaxia offers a valuable framework for understanding schizophrenia liability.
This conceptualization can guide the development of treatment and prevention strategies for schizophrenia.