Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth factor may decrease muscle atrophy secondary to denervation.

C S Day1, F Riano, M M Tomaino

  • 1Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, PA 15213, USA.

Journal of Reconstructive Microsurgery
|April 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of losartan or angiotensin II receptor antagonists on cartilage: a systematic review.

Osteoarthritis and cartilage·2022
Same author

Effect of elective surgery cancellations during the COVID-19 pandemic on patients' activity, anxiety and pain.

The British journal of surgery·2021
Same author

[Impact of the Lubrizol Rouen plant fire of September 26, 2019 on ophthalmic emergency room visits].

Journal francais d'ophtalmologie·2021
Same author

Bone morphogenetic proteins for articular cartilage regeneration.

Osteoarthritis and cartilage·2018
Same author

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.

Nature communications·2017
Same author

A Rare Case of an Early Postoperative Obstructive Ileus in a Young Female Patient due to a Residual Trichobezoar Mass.

Case reports in surgery·2016
Same journal

Interest in Robotics Outpaces Access: Results from A Survey of Practicing Plastic Surgeons.

Journal of reconstructive microsurgery·2026
Same journal

Enhancing Microvascular Anastomosis Using an Axial-View Microscope.

Journal of reconstructive microsurgery·2026
Same journal

Beyond BMI: Using Abdominal Wall Thickness to Guide Patient Selection for DIEP Flap Breast Reconstruction.

Journal of reconstructive microsurgery·2026
Same journal

Influence of Body Mass Index on Perioperative Outcomes of Oncologic Head and Neck Free Flaps: Comprehensive Analysis Using a Prospective Institutional Database.

Journal of reconstructive microsurgery·2026
Same journal

Homocysteine Levels as a Potential Contributor to Impaired Wound Healing in Plastic and Reconstructive Surgery.

Journal of reconstructive microsurgery·2026
Same journal

Infrared Temperature Monitoring in Vascularized Flaps with Simulated Arterial and Venous Thrombosis: An Animal Study.

Journal of reconstructive microsurgery·2026
See all related articles

Insulin growth factor-1 (IGF-1) may prevent muscle atrophy after nerve injury. Injecting IGF-1 into denervated mouse muscles helped preserve muscle size and strength, suggesting a therapeutic role.

Area of Science:

  • Muscle regeneration and atrophy research
  • Peripheral nerve injury and repair
  • Endocrinology and growth factors

Background:

  • Functional outcomes after brachial plexus reconstruction and peripheral nerve repair remain suboptimal.
  • Irreversible muscle atrophy often occurs before reinnervation, hindering recovery.
  • Insulin growth factor-1 (IGF-1) shows potential in improving muscle regeneration and preservation.

Purpose of the Study:

  • To evaluate histologic, immunohistochemical, and electrophysiologic changes in denervated muscle over 8 weeks.
  • To assess the effects of IGF-1 injection on denervated muscle preservation.

Main Methods:

  • Comparison of normal and denervated mouse gastrocnemius muscles over an 8-week period.
  • Histologic and immunohistochemical analysis of muscle tissue.

Related Experiment Videos

  • Electrophysiologic assessment of muscle contractile properties.
  • Injection of IGF-1 into denervated muscles at time zero for evaluation at 4 weeks.

    • Main Results:

    • Denervated muscles showed decreased diameter, weight, and strength, with early nuclear proliferation.
    • IGF-1 injection led to relative preservation of muscle diameter and weight compared to untreated denervated muscle.
    • IGF-1 treatment maintained electrophysiologic contractile properties in denervated muscles.

    Conclusions:

    • Denervation leads to significant muscle atrophy and functional decline over 8 weeks.
    • IGF-1 administration can mitigate muscle atrophy secondary to denervation.
    • These findings suggest IGF-1 as a potential therapeutic agent for preventing muscle loss after nerve injury.