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Scratching behavior in various strains of mice
1Department of Pharmacology, Gifu Pharmaceutical University, Mitahorahigashi, Gifu, Japan. inagakin@gifu-pu.ac.jp
Skin Pharmacology and Applied Skin Physiology
|April 24, 2001
Summary
ICR mice showed significant scratching responses to histamine and serotonin, unlike other strains. These findings suggest ICR mice are ideal for studying the mechanisms of itching and scratching behavior.
Area of Science:
- Immunology
- Neuroscience
- Pharmacology
Background:
- Itching is a common symptom with various underlying causes.
- Understanding the mechanisms of itch is crucial for developing effective treatments.
Purpose of the Study:
- To compare scratching behavior induced by different stimuli across 12 mouse strains.
- To identify a suitable mouse model for studying itch mediators and mechanisms.
Main Methods:
- Scratching behavior was induced using histamine, serotonin, substance P, and passive cutaneous anaphylaxis.
- Vascular permeability was measured in BALB/c, ICR, ddY, and NC/Nga mice.
- Scratching frequency was quantified and compared among 12 mouse strains.
Main Results:
- ICR mice exhibited frequent scratching behavior in response to histamine (50 nmol) and serotonin (50 nmol).
- Histamine, serotonin, substance P, and passive cutaneous anaphylaxis increased vascular permeability in BALB/c, ICR, ddY, and NC/Nga mice.
- ICR mice showed frequent scratching behavior to these four stimuli, while other strains showed limited responses.
Conclusions:
- ICR mice are highly responsive to various itch-inducing stimuli, particularly histamine.
- The ICR mouse strain is a suitable model for investigating the mediators and mechanisms of itching.