Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myosin diversity in Apicomplexa.

M B Heintzelman1, J D Schwartzman

  • 1Department of Anatomy, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

The Journal of Parasitology
|April 25, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apoptosis within mouse eye induced by Toxoplasma gondii.

Chinese medical journal·2002
Same author

Cryptogenic epilepsy: an infectious etiology?

Epilepsia·2001
Same author

Gamma delta T cell-deficient mice have a down-regulated CD8+ T cell immune response against Encephalitozoon cuniculi infection.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Identification and role of thiols in Toxoplasma gondii egress.

Experimental biology and medicine (Maywood, N.J.)·2001
Same author

Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes.

Gastroenterology·2001
Same author

Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same journal

REDESCRIPTION OF PARABENEDENIELLA POSTEROCOLPA (HARGIS, 1955) BRULE AND BULLARD N. GEN. ET N. COMB. (MONOGENOIDEA: CAPSALIDAE: ENTOBDELLINAE) FROM INFECTIONS ON THREE BATOID HOSTS (RHINOPTERIDAE AND MOBULIDAE) WITH PHYLOGENETIC ANALYSIS AND COMMENTS ABOUT CAPSALID HOST SPECIFICITY.

The Journal of parasitology·2026
Same journal

ASSOCIATION BETWEEN MACROCYCLIC LACTONE AND BENZIMIDAZOLE RESISTANCE IN THE DOG HOOKWORM ANCYLOSTOMA CANINUM.

The Journal of parasitology·2026
Same journal

TISSUE-SPECIFIC ORIGIN OF EGGS IN THE DEFINITIVE HOST DRIVES TRANSCRIPTOMIC AND BEHAVIORAL DIFFERENCES IN SCHISTOSOMA MANSONI MIRACIDIA.

The Journal of parasitology·2026
Same journal

DESCRIPTION, REDESCRIPTION, AND LIFE CYCLES OF PARORCHIS LAFFERTYI N. SP. AND PARORCHIS CATOPTROPHORI (TREMATODA: DIGENEA: PHILOPHTHALMIDAE) FROM THE CALIFORNIA HORN SNAIL, CERITHIDEOPSIS CALIFORNICA (GASTROPODA: POTAMIDIDAE).

The Journal of parasitology·2026
Same journal

CONFIRMATION OF SARCOCYSTIS INFECTIONS IN TONGUES OF FLORIDA PANTHERS (PUMA CONCOLOR CORYI).

The Journal of parasitology·2026
Same journal

MOLECULAR CHARACTERIZATION OF SARCOCYSTIS SPOROCYSTS IN INTESTINES OF BOBCAT (LYNX RUFUS) FROM MINNESOTA.

The Journal of parasitology·2026
See all related articles

Researchers screened seven Apicomplexan parasites for myosins using polymerase chain reaction (PCR). The study found limited myosin diversity, suggesting unique myosin evolution in these parasites.

Area of Science:

  • Parasitology
  • Molecular Biology
  • Biochemistry

Background:

  • Apicomplexan parasites cause significant diseases in humans and animals.
  • Myosins are essential motor proteins involved in various cellular functions.
  • Understanding myosin diversity in Apicomplexa is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the diversity of myosin genes in seven key Apicomplexan species.
  • To identify conserved and unique myosin classes within the Apicomplexa phylum.
  • To compare Apicomplexan myosins with those found in other eukaryotic organisms.

Main Methods:

  • Degenerate polymerase chain reaction (PCR) primers were designed to target conserved myosin regions.
  • PCR was performed on genomic DNA from seven Apicomplexan parasites.

Related Experiment Videos

  • Sequencing and analysis of amplified DNA fragments were conducted to identify putative myosin genes.

    • Main Results:

    • Putative myosin sequences were successfully obtained from all seven Apicomplexan species examined.
    • The identified sequences showed high similarity to known Apicomplexan myosins, indicating limited diversity.
    • Common myosin classes (I, II, and V) found across other eukaryotes were notably absent in Apicomplexa.

    Conclusions:

    • Apicomplexan parasites possess a restricted repertoire of myosin proteins.
    • These parasites may have evolved unique myosin classes tailored to their specific cellular functions.
    • The findings suggest a distinct evolutionary path for myosins in Apicomplexa, differing from plants and other eukaryotes.