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Asthma, asthma medication and autonomic nervous system dysfunction.

T Jartti1

  • 1The Department of Paediatrics, Turku University Central Hospital, Turku, Finland.

Clinical Physiology (Oxford, England)
|April 25, 2001
PubMed
Summary

Asthma involves autonomic nervous system imbalance, affecting airway function. Autonomic dysfunction in asthma may be linked to disease severity or adult medication use, not consistently seen in children.

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Area of Science:

  • Pulmonary Medicine
  • Autonomic Neuroscience

Background:

  • Asthma is linked to autonomic nervous system (ANS) imbalance, including heightened cholinergic constrictor sensitivity and potentially reduced beta2-adrenergic dilator sensitivity.
  • Non-adrenergic and non-cholinergic (NANC) mediators play a role in asthma pathogenesis by influencing airway smooth muscle tone, pulmonary blood flow, endothelial permeability, and secretions.

Purpose of the Study:

  • To review the complex relationships between airway inflammation, common asthma medications, and autonomic nervous system function in asthma.
  • To explore the discrepancies in findings regarding autonomic dysfunction in adult versus pediatric asthma populations.

Main Methods:

  • Literature review of studies investigating autonomic nervous system function in asthma.
  • Analysis of research on the impact of airway inflammation and asthma medications (beta2-agonists, anticholinergics, glucocorticoids) on ANS function.

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  • Comparison of findings in adult and pediatric asthma cohorts.

    • Main Results:

    • Increased parasympathetic responsiveness is frequently associated with clinical asthma severity in adults.
    • Autonomic dysfunction is not consistently observed in children with asthma, suggesting potential links to disease duration or medication history in adults.
    • NANC mediators contribute to airway regulation and asthma pathogenesis.

    Conclusions:

    • Autonomic nervous system dysfunction is a recognized feature in adult asthma, potentially related to disease progression or long-term treatment.
    • Further research is needed to clarify the role of ANS in pediatric asthma and its interaction with inflammation and medication.