Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Calcipotriol].

J J Guilhou1

  • 1Service de Dermatologie-Phlébologie, Hôpital Saint-Eloi, 80, avenue Augustin Fliche, 34295 Montpellier Cedex 5. jj-guilhou@chu-montpellier.fr

Annales De Dermatologie Et De Venereologie
|April 25, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation expérimentale de l'hydratation et du pouvoir occlusif in vivo et in vitro d'excipients lipophiles et de leurs émulsions phase huile continue.

International journal of cosmetic science·2009
Same author

The therapeutic effects of vitamin D3 and its analogues in psoriasis.

Expert opinion on investigational drugs·2005
Same author

Meyerson's phenomenon induced by interferon-alfa plus ribavirin in hepatitis C infection.

The British journal of dermatology·2005
Same author

Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin.

The British journal of dermatology·2004
Same author

Bromelain: an unusual cause of allergic contact cheilitis.

Contact dermatitis·2004
Same author

A prospective study of cutaneous adverse events induced by low-dose alpha-interferon treatment for malignant melanoma.

Dermatology (Basel, Switzerland)·2004
Same journal

2024 guidelines (S3) for the therapeutic management of patients with genital herpes.

Annales de dermatologie et de venereologie·2026
Same journal

Topical JAK inhibitors in the lichen planus spectrum: a systematic review.

Annales de dermatologie et de venereologie·2026
Same journal

2024 recommendations for the therapeutic management of anogenital warts.

Annales de dermatologie et de venereologie·2026
Same journal

Successful use of thalidomide in treating metastatic Crohn's disease.

Annales de dermatologie et de venereologie·2026
Same journal

Multiple cutaneous juvenile xanthogranuloma: a monocentric study.

Annales de dermatologie et de venereologie·2026
Same journal

Cartilage-hair-hypoplasia associated with granulomatosis induced by rubella vaccine.

Annales de dermatologie et de venereologie·2026
See all related articles

Calcipotriol, a synthetic vitamin D derivative, effectively treats psoriasis by reducing keratinocyte proliferation and inducing differentiation. It offers a favorable safety profile with minimal systemic effects at recommended doses.

Area of Science:

  • Dermatology and Pharmacology
  • Biochemistry and Molecular Biology

Context:

  • Calcipotriol is a synthetic vitamin D analogue developed for dermatological conditions.
  • Its mechanism involves regulating vitamin D-responsive genes, impacting keratinocyte behavior and immune responses.

Purpose:

  • To evaluate the efficacy and safety of Calcipotriol in treating psoriasis and other keratinization disorders.
  • To compare Calcipotriol's therapeutic profile against existing treatments and assess its potential in combination therapies.

Summary:

  • Calcipotriol reduces keratinocyte proliferation and promotes differentiation, with immunomodulatory effects.
  • Toxicology studies indicate safety at clinical doses, with minimal impact on calcium-phosphorus metabolism compared to calcitriol.
  • Clinical trials demonstrate Calcipotriol's superiority over placebos and some dermatocorticoids in psoriasis treatment.

Related Experiment Videos

  • It shows efficacy in combination therapies for psoriasis and potential benefits in ichthyoses, localized scleroderma, and vitiligo.
  • Adverse effects are typically localized skin irritations; systemic effects and contact dermatitis are rare.

    • Impact:

    • Calcipotriol provides an effective therapeutic option for psoriasis, offering advantages in combination treatments and potentially reducing the need for systemic therapies.
    • Its favorable safety profile and targeted action make it a valuable tool in managing various dermatological conditions.
    • Further research into long-term treatment protocols is warranted to optimize its clinical application.