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[Hydroa vacciniforme: dietary fish oil].

A B Modeste1, N Cordel, X Balguerie

  • 1Clinique Dermatologique, Unité INSERM U519, Hôpital Charles Nicolle, CHU de Rouen.

Annales De Dermatologie Et De Venereologie
|April 25, 2001
PubMed
Summary
This summary is machine-generated.

Dietary fish oil effectively treated hydroa vacciniforme, a rare childhood skin condition. This treatment, rich in omega-3 fatty acids, reduced inflammation and lesions, offering a new therapeutic option for this photodermatosis.

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Area of Science:

  • Dermatology
  • Photodermatology
  • Nutritional Science

Background:

  • Hydroa vacciniforme is a rare childhood photodermatosis with significant scarring potential.
  • Current treatments for hydroa vacciniforme have variable efficacy.
  • Dietary fish oil has been suggested as a potential therapeutic agent.

Observation:

  • A 15-year-old female presented with typical hydroa vacciniforme lesions.
  • Previous treatments including antimalarials and photoprotection were unsuccessful.
  • Administration of dietary fish oil (Maxepa®) led to rapid lesion regression.

Findings:

  • Dietary fish oil supplementation resulted in complete resolution of hydroa vacciniforme lesions within weeks.
  • The therapeutic effect was observed despite seasonal challenges (summer).
  • Treatment was interrupted due to side effects (fetid breath) but reintroduction also led to resolution.

Implications:

  • Dietary fish oil, rich in omega-3 polyunsaturated fatty acids, may reduce inflammation in hydroa vacciniforme.
  • This intervention could increase epidermal omega-3 fatty acids and decrease skin prostaglandins.
  • Fish oil represents a promising, albeit potentially poorly tolerated, treatment for hydroa vacciniforme.