Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does recombination improve selection on codon usage? Lessons from nematode and fly complete genomes.

G Marais1, D Mouchiroud, L Duret

  • 1Laboratoire "Biométrie et Biologie Evolutive," Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558, Bâtiment 711, Université Claude Bernard, Lyon 1, 69622 Villeurbanne Cedex, France.

Proceedings of the National Academy of Sciences of the United States of America
|April 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-host SARS-CoV-2 diversity in immunocompromised people living with HIV provides insight into the evolutionary trajectory of SARS-CoV-2.

Journal of virology·2025
Same author

The global impact of Wolbachia on mitochondrial diversity and evolution.

Journal of evolutionary biology·2017
Same author

Total anomalous pulmonary venous connection to unroofed coronary sinus diagnosed in a fetus with spinal muscular atrophy Type I.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2017
Same author

Comparative population genomics in animals uncovers the determinants of genetic diversity.

Nature·2014
Same author

Sex uncovered: the evolutionary biology of reproductive systems.

Journal of evolutionary biology·2014
Same author

Salbutamol: beware of the paradox!

BMJ case reports·2012
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Recombination influences codon usage bias in C. elegans and D. melanogaster. Contrary to expectations, this correlation is driven by mutation biases, not selection, highlighting recombination's mutagenic impact.

Area of Science:

  • Evolutionary genetics
  • Genomics
  • Molecular biology

Background:

  • Population genetics models predict selection efficacy correlates with recombination rate due to Hill-Robertson effects.
  • Codon usage bias, shaped by selection for translational efficiency, is thought to support this prediction.
  • Previous studies in Drosophila showed a positive correlation between codon usage bias and recombination rate.

Purpose of the Study:

  • To investigate the relationship between recombination rate and codon usage bias in complete genomes of C. elegans and D. melanogaster.
  • To determine whether selection or mutational patterns drive the observed correlation.

Main Methods:

  • Exhaustive analysis of codon usage patterns across the genomes of C. elegans and D. melanogaster.
  • Correlation analysis between local recombination rates and the frequency of optimal codons.

Related Experiment Videos

  • Investigation of underlying mutational biases in regions with varying recombination rates.

    • Main Results:

    • A positive correlation was observed between recombination rate and the frequency of optimal codons in both species.
    • This correlation is attributed to a mutational bias favoring G and C bases in high recombination regions.
    • The observed codon usage bias is primarily driven by recombination-dependent mutational patterns, not selective pressures.

    Conclusions:

    • The correlation between codon usage bias and recombination rate in C. elegans and D. melanogaster is largely explained by recombination-induced mutational biases.
    • Recombination's mutagenic effects must be considered to accurately understand its evolutionary role.
    • Selection on codon usage may be less influenced by recombination than previously assumed.