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Dynamics of Fos-Jun-NFAT1 complexes

V R Ramirez-Carrozzi1, T K Kerppola

  • 1Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0650, USA.

Proceedings of the National Academy of Sciences of the United States of America
|April 26, 2001
PubMed
Summary

The orientation of Fos-Jun heterodimers in transcription complexes is influenced by NFAT1, affecting complex stability and gene activation. This binding orientation impacts both the dynamics and promoter selectivity of these regulatory complexes.

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