Candida albicans colonization of surface-sealed interim soft liners

Area of Science:

• Oral Microbiology
• Biomaterials Science
• Prosthodontics

Background:

• Denture liners are susceptible to microbial colonization, potentially leading to oral health issues.
• Soft interim denture liners, while comfortable, may offer a favorable environment for microbial growth.
• Preventing microbial adhesion on denture surfaces is crucial for maintaining oral hygiene and preventing infections.

Purpose of the Study:

• To evaluate the efficacy of two denture sealer agents, Palaseal and Mono-Poly, in preventing microbial colonization on a soft interim denture liner.
• To assess the in vivo effect of these sealants on yeast and bacterial colonization over a 14-day period.
• To compare the performance of Palaseal and Mono-Poly in reducing microbial load on denture liners.

Main Methods:

• An in vivo study using 10 maxillary complete dentures with soft interim denture liners (Coe-Soft).
• Denture liner surfaces were treated with Palaseal, Mono-Poly, or left unsealed (control).
• Samples were exposed to the oral cavity for 14 days, followed by microbiological analysis to quantify yeast and bacterial colonization.

Main Results:

• Both Palaseal and Mono-Poly significantly reduced yeast and bacterial colonization compared to unsealed controls (p <.001).
• No statistically significant difference was observed between Palaseal and Mono-Poly in their ability to prevent total yeast or bacterial colonization (p < .005).
• The sealed soft liner materials demonstrated markedly lower microbial adhesion.

Conclusions:

• Coating the Coe-Soft denture liner with either Palaseal or Mono-Poly effectively decreases yeast and bacterial colonization.
• Denture surface sealants represent a viable strategy for enhancing the hygiene of interim soft denture liners.
• Further research may explore the long-term efficacy and patient-reported outcomes of these sealing agents.