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[Radiochemotherapy plus hyperthermia in rectal carcinoma].
1Charité: Campus Berlin Buch, Humboldt Universität zu Berlin, Robert-Rössle-Klinik, Berlin. rau@rrk-berlin.de
Praxis
|April 26, 2001
Summary
Preoperative radiochemotherapy combined with hyperthermia improves surgical outcomes for locally advanced rectal cancer. This combined treatment enhances resectability and reduces local recurrence, offering better control and survival rates.
Area of Science:
- Oncology
- Radiation Oncology
- Surgical Oncology
Background:
- Locally advanced rectal cancer (uT3/uT4) presents challenges in resectability and local control.
- Preoperative radiochemotherapy has shown promise in improving outcomes for such cases.
Purpose of the Study:
- To evaluate the efficacy of combined preoperative radiochemotherapy and hyperthermia in locally advanced rectal cancer.
- To assess the impact on resectability, local control, and survival rates.
Main Methods:
- Patients received preoperative radiochemotherapy (5 x 1.8 Gy up to 45 Gy) with 5-Fluorouracil and Leucovorin.
- Regional hyperthermia using SIGMA 60 applicator BSD 2000 was administered weekly prior to radiotherapy.
- Surgery was performed 4-6 weeks after the combined preoperative treatment.
Main Results:
- The study achieved a high resectability rate of up to 90%.
- A response rate to the treatment was observed in 60% of patients.
- Therapeutic toxicity was found to be acceptable.
Conclusions:
- Combined preoperative radiochemotherapy and hyperthermia demonstrate encouraging downstaging in locally advanced rectal cancer.
- This multimodal approach leads to improved local control and survival rates.
- The treatment strategy is associated with acceptable toxicity and high resectability.