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Factor VII levels in patients undergoing coronary angiography: factor VII and coronary artery disease
1Department of Cardiology, Istanbul University, Cerrahpaşa Medical Faculty, Turkey.
Insights
Factor VII (F VII) levels are elevated in patients with prior coronary events but do not independently predict coronary artery disease (CAD) severity or progression.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Atherosclerosis Research
Background:
- Factor VII (F VII) is implicated in coronary atherosclerosis, yet its role in coronary artery disease (CAD) progression remains debated.
- Investigating F VII levels in patients with established CAD is crucial for understanding its association with disease characteristics and outcomes.
Purpose of the Study:
- To examine the relationship between Factor VII (F VII) levels and the severity of coronary artery disease (CAD).
- To assess the association of F VII with coronary events and other atherosclerosis risk factors.
Main Methods:
- Patients undergoing coronary angiography were stratified into CAD (n=155), high-risk (n=54), and control (n=90) groups.
- F VII levels were measured and analyzed concerning the number of diseased coronary vessels and history of coronary events.
Main Results:
- Mean F VII levels did not differ significantly across the three patient groups.
- Within the CAD group, F VII levels correlated positively with the number of involved coronary vessels.
- Patients with a history of coronary events exhibited higher F VII levels compared to those without.
Conclusions:
- Elevated Factor VII (F VII) levels are observed in patients with previous coronary events.
- F VII is not identified as an independent risk factor for the progression or severity of coronary artery disease (CAD).
Background:
Factor VII (F VII) has been widely investigated as a risk factor for coronary atherosclerosis, however there is still debate about its role in the progression of coronary artery disease (CAD). In this study F VII levels were measured in patients with angiographically proven CAD and its relation with disease severity, coronary events and with other risk factors of coronary atherosclerosis were examined.
Methods:
Consecutive patients referred to coronary angiography were divided in three groups: 1. CAD group--those with a significant lesion in one or more coronary arteries (n = 155), 2. High-risk group--patients with normal coronary arteries and with two or more risk factors (n = 54), 3. Controls--patients with normal coronary arteries and with no or one risk factor (n = 90). CAD group was also studied according to the number of vessels involved and to the history of coronary events.
Results:
Mean F VII levels were not different between the three groups of patients. In CAD group, F VII increased parallel to the number of vessels involved (one vessel disease: 85 +/- 20%, two vessel disease: 92 +/- 23%, three vessel disease: 105 +/- 23%). Patients with a history of coronary events had significantly higher F VII levels than those without such a history (96 +/- 25% versus 89 +/- 22% respectively, P = 0.02). However, logistic regression analysis revealed no significant relation between F VII and either the presence of CAD or coronary events.
Conclusions:
F VII levels increase in patients with previous coronary events, but it is not an independent risk factor for the progression or for the severity of CAD.