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Antidiabetic effect of Oenanthe javanica flavone
1Department of Pharmacology, Beijing Medical College of PLA, 8 Dongdajie Road, Beijing 100071, China. Simbalee@Publica.bj.cninfo.net
Aim:
To study the antidiabetic effect of Oenanthe javanica flavone (OjF).
Methods:
Mice were injected i.v. with alloxan 90 mg.kg-1 to induce diabetes. Blood glucose, serum lipid, and pancreatic amylase were determined with Automatic Biochemistry Analysor. Serum insulin was determined by radioimmunoassay. The pancreas and islets were examined under microscope.
Results:
OjF 200 mg.kg-1 reduced the blood glucose in normal mice from 0.5 to 6 h after a single administration ig. OjF 200 and 400 mg.kg-1 ig daily for 10 d decreased the blood glucose in alloxan-induced hyperglycemic mice (P < 0.05, P < 0.01). OjF promoted the release of insulin both in normal and in diabetic mice. OjF decreased serum triglyceride and raised the lowered pancreatic amylases in diabetic mice (P < 0.01, P < 0.01). The islet-injured changes of OjF-treated group were similar to those of control in histology examination, but to a lesser degree.
Conclusion:
OjF possessed the hypoglycemic and hypotriglyceride actions, mainly concerned with promoting release of insulin from B-cells in islets of langerhans.
Insights
Oenanthe javanica flavone (OjF) effectively lowers blood glucose and triglycerides in diabetic mice. This antidiabetic effect is linked to OjF promoting insulin release from pancreatic beta cells.
Area of Science:
- Pharmacology
- Endocrinology
- Natural Products Chemistry
Background:
- Diabetes mellitus is a significant metabolic disorder characterized by hyperglycemia.
- Alloxan-induced diabetes in mice is a common model for studying antidiabetic agents.
- Oenanthe javanica flavone (OjF) is a plant-derived compound with potential therapeutic properties.
Purpose of the Study:
- To investigate the antidiabetic effects of Oenanthe javanica flavone (OjF).
- To evaluate the impact of OjF on glucose metabolism and related biomarkers in a mouse model.
Main Methods:
- Diabetes was induced in mice using a single intravenous injection of alloxan (90 mg/kg).
- Blood glucose, serum lipids, and pancreatic amylase levels were measured using an Automatic Biochemistry Analyzer.
- Serum insulin was quantified via radioimmunoassay, and pancreatic tissue was examined histologically.
Main Results:
- OjF administration (200 mg/kg) reduced blood glucose in normal mice and significantly decreased hyperglycemia in alloxan-induced diabetic mice.
- OjF treatment promoted insulin release in both normal and diabetic mice.
- OjF lowered serum triglyceride levels and improved pancreatic amylase activity in diabetic mice, with histological examination showing less islet injury.
Conclusions:
- Oenanthe javanica flavone (OjF) exhibits significant hypoglycemic and hypotriglyceridemic effects.
- The antidiabetic mechanism of OjF primarily involves the promotion of insulin release from pancreatic beta cells.
- OjF demonstrates potential as a therapeutic agent for managing diabetes.