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Related Experiment Videos

Lysophosphatidic acid synthesis and release.

C Pagès1, M F Simon, P Valet

  • 1INSERM U317, Institut Louis Bugnard, Université Paul Sabatier, CHU Rangueil, Toulouse, France.

Prostaglandins & Other Lipid Mediators
|April 28, 2001
PubMed
Summary

Lysophosphatidic acid (LPA), a bioactive phospholipid, regulates cellular functions via G-protein coupled receptors. This review details LPA synthesis, degradation, transport, and its role in diseases like cancer and obesity.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Lysophosphatidic acid (LPA) is a bioactive phospholipid.
  • It modulates cellular responses by activating specific G-protein coupled receptors.
  • LPA is found in biological fluids and secreted by various cell types.

Purpose of the Study:

  • To review enzymes involved in LPA synthesis and degradation.
  • To discuss molecules facilitating LPA transport.
  • To analyze LPA's role in physio-pathological conditions and disease genesis.

Main Methods:

  • Literature review of enzymes (acyltransferases, phospholipases, kinases, lysophospholipases, lipid-phosphatases).
  • Examination of LPA transport molecules (albumin, FABPs, gelsolin, lipoproteins).

Related Experiment Videos

  • Analysis of LPA's involvement in aggregation, cancer, injuries, obesity, and arteriosclerosis.

    • Main Results:

    • Multiple synthesis and degradation pathways exist, but their extracellular contribution is debated.
    • Various enzymes and transport proteins are identified.
    • LPA is associated with several pathological conditions.

    Conclusions:

    • Understanding LPA metabolism and transport is crucial.
    • LPA plays a significant role in various diseases.
    • Further research is needed to clarify LPA's precise contribution to disease pathogenesis.