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Related Experiment Videos

Calcium signaling and annexins.

T E Hawkins1, C J Merrifield, S E Moss

  • 1Laboratory for Molecular Cell Biology, University College London, UK.

Cell Biochemistry and Biophysics
|April 28, 2001
PubMed
Summary

Annexins are calcium-binding proteins with emerging roles as ion channels and regulators. This review explores their potential in intracellular calcium signaling and ion flux control.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Physiology

Background:

  • Annexins are a family of calcium ion (Ca2+)-binding proteins with largely unknown physiological functions.
  • Proposed roles include vesicle trafficking, but this review focuses on their potential as ion channels or regulators.

Purpose of the Study:

  • To review the evidence for annexins acting as atypical ion channels or modulators of ion channel activity.
  • To explore the proposed roles of annexins in intracellular calcium (Ca2+) signaling and homeostasis.

Main Methods:

  • Review of in vitro and structural analyses of annexin proteins.
  • Examination of evidence for annexin roles in intracellular Ca2+ signaling.
  • Analysis of structural and electrophysiological data.

Main Results:

  • Increasing evidence suggests some annexins function in intracellular Ca2+ signaling.
  • Annexins may act as atypical ion channels and/or modulators of ion channel activity.
  • Structural and electrophysiological data support roles in controlling ion fluxes.

Conclusions:

  • Annexins show potential as key players in intracellular calcium homeostasis.
  • Further research is needed to fully elucidate the physiological roles of annexins in ion transport.

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