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Does blood of healthy subjects contain bacterial ribosomal DNA?
S Nikkari1, I J McLaughlin, W Bi
1Department of Microbiology and Immunology and Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. snikkari@cmgm.stanford.edu
Journal of Clinical Microbiology
|April 28, 2001
Abstract:
Real-time PCR methods with primers and a probe targeting conserved regions of the bacterial 16S ribosomal DNA (rDNA) revealed a larger amount of rDNA in blood specimens from healthy individuals than in matched reagent controls. However, the origins and identities of these blood-associated bacterial rDNA sequences remain obscure.