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[Proteinkinase B/Akt].

M Kubota1

  • 1Department of Neuropsychiatry, Yamanashi Medical University, Shimogato 1110, Tamaho, Yamanashi, 409-3898 Japan.

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|May 1, 2001
PubMed
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Protein kinase B/Akt (a key cell regulator) plays a vital role in cell survival and proliferation. Its activity is influenced by factors relevant to psychiatric conditions, suggesting therapeutic potential.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Neuroscience

Background:

  • Protein kinase B/Akt (Akt) is a serine/threonine kinase identified in 1991.
  • Akt activation occurs at Thr308 and Ser473 residues.
  • Activated Akt regulates glycogen synthesis, protein synthesis, and crucially, cell survival and proliferation.

Purpose of the Study:

  • To explore the role of Protein Kinase B/Akt in cellular processes.
  • To investigate the impact of genetic mutations and pharmacological agents on Akt activity.
  • To assess the relevance of Akt signaling in psychiatric contexts.

Main Methods:

  • Literature review of recent findings on Akt.
  • Analysis of studies reporting Akt modulation by mutant presenilin-1.
  • Examination of research on lithium's effect on Akt activity.

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Main Results:

  • Mutant presenilin-1 has been shown to downregulate Akt.
  • Lithium treatment has been reported to alter Akt activity.
  • Akt signaling is implicated in fundamental cellular functions including survival and proliferation.

Conclusions:

  • Protein kinase B/Akt is a critical regulator of cell survival and proliferation.
  • Modulation of Akt by factors like mutant presenilin-1 and lithium suggests its involvement in disease pathways.
  • The influence of Akt on cellular processes indicates its potential significance in psychiatric disorders.