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[BMAL1 and circadian rhythm].

M Ikeda1

  • 1Department of Physiology, Saitama Medical School, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan.

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|May 1, 2001
PubMed
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Researchers identified the human BMAL1 (brain and muscle ARNT-like protein 1) transcription factor, crucial for circadian rhythms. BMAL1 forms a complex with CLOCK, regulating genes involved in the body's internal clock.

Area of Science:

  • * Molecular Biology
  • * Chronobiology
  • * Genetics

Context:

  • * The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals.
  • * Circadian rhythms regulate various physiological processes.
  • * The molecular mechanisms underlying circadian rhythmicity are complex.

Purpose:

  • * To clone and characterize the human BMAL1 (brain and muscle ARNT-like protein 1) gene.
  • * To investigate the expression patterns of rBmal1 mRNA in the rat brain and peripheral organs.
  • * To elucidate the interaction between BMAL1 and CLOCK proteins in regulating circadian gene expression.

Summary:

  • * Human BMAL1, a novel bHLH-PAS transcription factor, was cloned from a human brain cDNA library.
  • * rBmal1 mRNA exhibited high expression in the rat SCN, exhibiting a circadian rhythm, and was also found in other brain regions and peripheral organs.

Related Experiment Videos

  • * Yeast two-hybrid screening confirmed that CLOCK forms a heterodimer with BMAL1, which binds to the E-box in the mPer1 promoter, inhibiting its own transcription and forming a core component of the circadian clock feedback loop.

    • Impact:

    • * This study identifies BMAL1 as a key component of the mammalian circadian clock.
    • * Understanding the BMAL1-CLOCK interaction provides insights into the molecular basis of circadian rhythms.
    • * Findings contribute to the broader understanding of gene regulation and biological timing mechanisms.