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[The protective effect of removing circulatory TNF by immuno-adsorption on endotoxin-induced acute lung injury]
Objective:
To study the protective effect of removing circulatory TNF by immunoadsorption on endotoxin-induced acute lung injury in rabbits.
Method:
New Zealand white rabbits injected with lethal dose of endotoxin underwent hemoperfusion with immunoadsorbent. TNF and IL-8 levels in BALF were measured, the number of leukocytes and percentage of PMN in BALF were analyzed and the ratio of wet lung to body weight and pulmonary microvascular permeability index were also studied. In addition, the survival rate was observed.
Result:
Treatment with immunoadsorption markedly attenuated the pulmonary microvascular permeability increased by endotoxin and improved the survival rate.
Conclusion:
Immunoadsorption to remove circulating TNF is an effective way to protect rabbits against endotoxin-induced acute lung injury.
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