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Growth hormone binding protein 2001.

G Baumann1

  • 1Department of Medicine, Northwestern University Medical School, Chicago, IL, USA. gbaumann@northwestern.edu

Journal of Pediatric Endocrinology & Metabolism : JPEM
|May 1, 2001
PubMed
Summary
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Growth hormone binding protein (GHBP), the ectodomain of the growth hormone receptor (GHR), plays complex roles in regulating growth hormone (GH) action. GHBP levels often reflect GHR status and can aid in diagnosing GHR deficiencies.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Background:

  • Growth hormone binding protein (GHBP) is the circulating ectodomain of the growth hormone receptor (GHR).
  • GHBP is conserved across vertebrates and produced via GHR mRNA splicing or proteolytic cleavage, with TACE as a likely enzyme.
  • Its distribution in biological fluids varies, impacting growth hormone (GH) availability and action.

Purpose of the Study:

  • To review the current knowledge on GHBP, focusing on its high-affinity form.
  • To elucidate the production, functions, and physiological significance of GHBP.
  • To explore the diagnostic utility of GHBP levels in relation to GHR status.

Main Methods:

  • Literature review of studies on GHBP and GHR.
  • Analysis of GHBP production mechanisms (splicing vs. cleavage).

Related Experiment Videos

  • Examination of GHBP's interactions with GH and GHR.

    • Main Results:

    • GHBP binds approximately 50% of circulating GH, acting as a buffer and prolonging GH half-life.
    • Serum GHBP levels generally parallel GHR expression, declining with age and increasing during rodent pregnancy.
    • Low GHBP levels correlate with GH resistance (e.g., malnutrition, diabetes), while obesity shows elevated levels.
    • GHBP measurement is diagnostically valuable for Laron syndrome (GHR deficiency), with low levels in 75-80% of patients.

    Conclusions:

    • GHBP has complex, partly enhancing and partly inhibitory effects on GH action in vivo.
    • GHBP levels serve as an indicator of GHR status in various physiological and pathological conditions.
    • Further research is needed to fully establish the ultimate biological role and physiological significance of GHBP.