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Updated: Sep 10, 2026

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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach
B Karwowski1, A Okruszek, J Wengel
1Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódź.
Bioorganic & Medicinal Chemistry Letters
|May 1, 2001
Abstract:
The application of the oxathiaphospholane approach for the stereocontrolled synthesis of LNA dinucleoside phosphorothioate is described. The reaction of ring opening condensation proceeds in CH3CN solution in high yield and with over 96% stereoselectivity. One of diastereomers of LNA dinucleoside phosphorothioate (presumably R(P)) was found to be readily digested by svPDE.

