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Dimeric L-dopa derivatives as potential prodrugs
A Di Stefano1, B Mosciatti, G M Cingolani
1Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti, Italy. adistefano@unich.it
Bioorganic & Medicinal Chemistry Letters
|May 1, 2001
Abstract:
A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.