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Pancreatic concentrations of cefepime.
R Delcenserie1, M P Dellion-Lozinguez, T Yzet
1Services d'Hépatogastroentérologie, Centre Hospitalo-Universitaire Nord, 80054 Amiens Cedex, France. delcenserie.richard@chu-amiens.fr
The Journal of Antimicrobial Chemotherapy
|May 1, 2001
Summary
Cefepime demonstrates significant concentrations in pancreatic tissues and fluids, suggesting its potential utility for preventing and treating pancreatic infections. This antibiotic shows promise in managing complex abdominal infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Gastroenterology
Background:
- Pancreatic infections pose significant clinical challenges.
- Effective antibiotic penetration into pancreatic tissues and fluids is crucial for successful treatment.
- Limited data exists on the pharmacokinetic profile of advanced cephalosporins in pancreatic fluid compartments.
Purpose of the Study:
- To quantify cefepime concentrations in pancreatic pseudocyst fluid, pancreatic tissue, and pancreatic fistula fluid.
- To assess cefepime penetration into these pancreatic compartments following intravenous administration.
- To evaluate the potential of cefepime as an therapeutic agent for pancreatic infections.
Main Methods:
- Nine patients received a single 2g intravenous dose of cefepime.
- Plasma, pancreatic pseudocyst fluid, pancreatic tissue, and pancreatic fistula fluid samples were collected.
- Cefepime concentrations were measured using validated analytical methods.
Main Results:
- Mean plasma cefepime concentration was 27.4 mg/L between 120-200 min post-infusion.
- Mean cefepime concentrations were 6.3 mg/L in pancreatic pseudocyst fluid and 10.7 mg/L in pancreatic tissue.
- Cefepime was detected in pancreatic fistula fluid within 30 min and persisted for 8 hours.
Conclusions:
- Cefepime achieves therapeutic concentrations in pancreatic tissues and fluids.
- These findings support the potential use of cefepime for the prophylaxis and treatment of pancreatic infections.
- Further clinical studies are warranted to confirm efficacy in diverse pancreatic infection scenarios.