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Role of the central nervous system in hemopoiesis regulation during experimental neuroses

E G Skurikhin1, A M Dygai, N I Suslov

  • 1Laboratory of Pathophysiology and Experimental Therapy, Group of Psychopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

Bulletin of Experimental Biology and Medicine
|May 1, 2001
PubMed

Pharmacological blockade of dopamine- and serotoninergic structures with haloperidol and cyproheptadine, respectively, attenuated hyperplasia of bone marrow granulocytopoiesis and erythropoiesis (cyproheptadine) caused by conflict situation. At the same time, haloperidol and, especially, cyproheptadine normalized suppressed erythropoiesis and modulated activated granulocytopoiesis under conditions of paradoxical sleep deprivation. These results indicate that central regulation of hemopoietic stems is mediated by different neurotransmitter mechanisms. Erythropoiesis depends on the state of serotoninergic structures, while granulocytopoiesis is regulated both by the dopamine- and serotoninergic systems.

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