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Related Experiment Videos

Initial experience with fenoldopam in children.

L M Strauser1, R D Pruitt, J D Tobias

  • 1Department of Child Health, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, MI 65212, USA.

American Journal of Therapeutics
|May 1, 2001
PubMed
Summary

Fenoldopam effectively controlled blood pressure in children across various critical care situations. This study reviews its pediatric applications and suggests appropriate dosing regimens for managing hypertensive emergencies.

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Area of Science:

  • Pharmacology
  • Pediatric Critical Care
  • Cardiovascular Medicine

Background:

  • Fenoldopam is a selective dopamine 1 receptor agonist, acting as a direct vasodilator.
  • It lowers mean arterial pressure (MAP) by dilating renal, coronary, cerebral, and splanchnic arteries.
  • Preliminary adult data suggest efficacy in hypertensive urgencies and emergencies.

Observation:

  • This case series details fenoldopam use in four pediatric patients.
  • Fenoldopam was employed in diverse clinical settings, including hypertensive emergencies and urgencies.
  • It was also utilized for intraoperative controlled hypotension and during extracorporeal membrane oxygenation (ECMO).

Findings:

  • Fenoldopam demonstrated utility in managing pediatric hypertensive crises.

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  • It proved effective in achieving controlled hypotension during surgery.
  • The drug helped stabilize MAP in critically ill children on ECMO.

    • Implications:

    • Fenoldopam represents a potential therapeutic option for pediatric hypertension management.
    • Further research into pediatric dosing and long-term outcomes is warranted.
    • This review provides insights into fenoldopam's application and dosing in pediatric critical care settings.