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Related Experiment Videos

Initial experience with fenoldopam in children.

L M Strauser1, R D Pruitt, J D Tobias

  • 1Department of Child Health, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, MI 65212, USA.

American Journal of Therapeutics
|May 1, 2001
PubMed
Summary
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Fenoldopam effectively controlled blood pressure in children across various critical care situations. This study reviews its pediatric applications and suggests appropriate dosing regimens for managing hypertensive emergencies.

Area of Science:

  • Pharmacology
  • Pediatric Critical Care
  • Cardiovascular Medicine

Background:

  • Fenoldopam is a selective dopamine 1 receptor agonist, acting as a direct vasodilator.
  • It lowers mean arterial pressure (MAP) by dilating renal, coronary, cerebral, and splanchnic arteries.
  • Preliminary adult data suggest efficacy in hypertensive urgencies and emergencies.

Observation:

  • This case series details fenoldopam use in four pediatric patients.
  • Fenoldopam was employed in diverse clinical settings, including hypertensive emergencies and urgencies.
  • It was also utilized for intraoperative controlled hypotension and during extracorporeal membrane oxygenation (ECMO).

Findings:

  • Fenoldopam demonstrated utility in managing pediatric hypertensive crises.

Related Experiment Videos

  • It proved effective in achieving controlled hypotension during surgery.
  • The drug helped stabilize MAP in critically ill children on ECMO.

    • Implications:

    • Fenoldopam represents a potential therapeutic option for pediatric hypertension management.
    • Further research into pediatric dosing and long-term outcomes is warranted.
    • This review provides insights into fenoldopam's application and dosing in pediatric critical care settings.