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Related Experiment Videos

Relationship between bone marrow cellularity and apparent diffusion coefficient.

Y Nonomura1, M Yasumoto, R Yoshimura

  • 1Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. yasumoto.mrad@med.tmd.ac.jp

Journal of Magnetic Resonance Imaging : JMRI
|May 1, 2001
PubMed
Summary
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Apparent diffusion coefficient (ADC) of bone marrow positively correlates with cellularity. Higher cellularity, including lymphoma-related hypercellularity, shows higher ADC values, while hypocellular marrow has the lowest ADC.

Area of Science:

  • Radiology
  • Biomedical Imaging
  • Oncology

Background:

  • Bone marrow cellularity varies with age and disease states.
  • Diffusion-weighted imaging (DWI) is a non-invasive MRI technique.
  • Apparent diffusion coefficient (ADC) quantifies water molecule diffusion in tissues.

Purpose of the Study:

  • To investigate the relationship between bone marrow cellularity and ADC values.
  • To assess if ADC can differentiate varying degrees of bone marrow cellularity.
  • To evaluate ADC in normal and lymphoma-related hypercellular bone marrow.

Main Methods:

  • Diffusion-weighted echo-planar imaging was used to acquire 66 ADC values.
  • Studies included four groups: normal hypocellular, normocellular, hypercellular adult marrow, and lymphoma-related hypercellular marrow.

Related Experiment Videos

  • Bone marrow biopsies confirmed cellularity in adult subjects.

    • Main Results:

    • Hypercellular bone marrow (normal and lymphoma-related) exhibited the highest mean ADC.
    • Hypocellular bone marrow demonstrated the lowest mean ADC.
    • Statistically significant differences in ADC were observed among normal hypocellular, normocellular, and hypercellular marrow groups.

    Conclusions:

    • A positive correlation exists between bone marrow cellularity and ADC values.
    • ADC measurements can potentially differentiate bone marrow cellularity.
    • DWI may offer a non-invasive method for assessing bone marrow cellularity in conditions like lymphoma.