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Pulse wave velocity as endpoint in large-scale intervention trial. The Complior study. Scientific, Quality Control,

R Asmar1, J Topouchian, B Pannier

  • 1L'Institut CardioVasculaire, Paris, France. ra@icv.org

Journal of Hypertension
|May 2, 2001
PubMed

Insights

This study shows that antihypertensive therapy effectively reduces blood pressure and arterial stiffness in hypertensive patients. The Complior device demonstrated feasibility for large-scale trials measuring pulse wave velocity (PWV).

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Clinical Trials

Background:

  • Arterial stiffness, a marker of cardiovascular risk, is often elevated in hypertensive patients.
  • Measuring arterial stiffness using pulse wave velocity (PWV) can provide valuable prognostic information.

Purpose of the Study:

  • To assess the impact of antihypertensive therapy on arterial stiffness, measured by carotid-femoral pulse wave velocity (PWV).
  • To evaluate the feasibility of using PWV as an endpoint in a large-scale intervention trial for hypertension.

Main Methods:

  • A 6-month intervention study involving 1,703 hypertensive patients across 19 countries.
  • Patients received perindopril (ACE inhibitor) and indapamide (diuretic) as needed.
  • Carotid-femoral PWV and blood pressure were measured at baseline, 2 months, and 6 months using the Complior device.

Main Results:

  • Significant reductions in both systolic and diastolic blood pressure were observed.
  • A statistically significant decrease in carotid-femoral PWV was achieved.
  • The Complior device proved feasible for large-scale PWV measurements in hypertensive patients.

Conclusions:

  • Antihypertensive therapy, including ACE inhibitors and diuretics, can improve arterial stiffness in hypertensive individuals.
  • The Complior Study successfully demonstrated the feasibility of large-scale intervention trials utilizing PWV as a primary endpoint.
  • Further long-term controlled studies are warranted to confirm these findings.
Abstract

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