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Can estrogen influence the response to noxious stimuli?
1Department of Anesthesia, Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Itsen@zeus.bwh.harvard.edu
Study Objectives:
To evaluate estrogen-induced alternations in noxious stimuli response.
Design:
Randomized, prospective, double-blind study.
Settings:
Tertiary-care academic medical center.
Patients:
40 ASA physical status I and II women at the beginning and conclusion of an in vitro fertilization stimulation cycle.
Interventions:
Stimuli were applied to the fingers of the dominant hand via a Basile Analgesy-Meter, which applied increasing pressure (g/cm(2)) in a continuous fashion, and ice water immersion.
Measurements:
Serum hormonal concentrations and responses to noxious (pressure and cold thermal) stimuli were studied.
Main Results:
Estrogen and progesterone concentrations changed from 377 +/- 323.42 pg/mL to 2078.05 +/- 1175.92 pg/mL (p < 0.001) and 1.20 +/- 0.56 to 1.03 +/- 0.35 ng/mL (p = NS), respectively. Although no significant difference was noted in the response to pressure (16.92 +/- 4.41 to 17.85 +/- 4.95 g/cm(2)), a significant reduction in the tolerance to ice water immersion (34.18 +/- 28.29 to 24.05 +/- 23.02 s) was observed.
Conclusions:
High estrogen concentrations are associated with significantly lower tolerance to cold, but not pressure stimuli.
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