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Unusual aspects of breast cancer: case 2. Synchronous bilateral lung and breast cancers

H J Burstein1, S J Swanson, R L Christian

  • 1Dana-Farber Cancer Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|May 2, 2001
PubMed
Abstract

No abstract available in PubMed .

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...