Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coding specificity in cortical microcircuits: a multiple-electrode analysis of primate prefrontal cortex.

C Constantinidis1, M N Franowicz, P S Goldman-Rakic

  • 1Section of Neurobiology, Yale School of Medicine, New Haven, Connecticut 06510, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain Charts for the Rhesus Macaque Lifespan.

bioRxiv : the preprint server for biology·2024
Same author

Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI.

AJNR. American journal of neuroradiology·2023
Same author

Enhancement of metabolic activity in the diencephalon of monkeys performing working memory task: a 2-deoxyglucose study in behaving rhesus monkeys.

Journal of cognitive neuroscience·2013
Same author

Prospective, open-label, randomized, phase III study of two dose-dense regimens MVAC versus gemcitabine/cisplatin in patients with inoperable, metastatic or relapsed urothelial cancer: a Hellenic Cooperative Oncology Group study (HE 16/03).

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same author

The use of 24-h ambulatory blood pressure monitoring (ABPM) during the first cycle of sunitinib improves the diagnostic accuracy and management of hypertension in patients with advanced renal cancer.

European journal of cancer (Oxford, England : 1990)·2011
Same author

Antipsychotics and working memory in schizophrenia.

Science (New York, N.Y.)·2007
Same journal

Vestibular function drives gaze stability in locomoting macaques.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Neurons in the prefrontal cortex (PFC) coordinate during spatial working memory tasks. Nearby neurons with similar response properties show correlated activity, suggesting local circuit organization.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Prefrontal cortex (PFC) neurons exhibit directional specificities during spatial working memory tasks.
  • Coordination of PFC neuronal activity is hypothesized to involve recurrent connections, but direct physiological evidence is limited.

Purpose of the Study:

  • To investigate the functional organization of the working memory system in vivo.
  • To characterize effective connectivity between simultaneously recorded PFC neurons.
  • To relate neuronal connectivity to spatial and temporal response properties.

Main Methods:

  • Simultaneous multi-neuron recordings in monkeys performing a delayed oculomotor response task.
  • Cross-correlation analysis to assess neuronal synchrony and effective connectivity.

Related Experiment Videos

  • Analysis of neuronal firing patterns in relation to spatial tuning and temporal activation profiles.

    • Main Results:

    • Narrow cross-correlation peaks, indicative of common input, were most frequent between nearby neurons (<0.3 mm).
    • Correlated discharge was strongest between neurons with similar spatial tuning and temporal activation profiles.
    • These functional correlations were observed during task performance and baseline fixation.

    Conclusions:

    • Local circuits in the prefrontal cortex are functionally organized.
    • Neuronal coding specificity extends to the local circuit level.
    • Spatial and temporal response properties shape the effective connectivity of PFC neurons.