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Twins and cerebral palsy.

P O Pharoah1

  • 1Department of Public Health, University of Liverpool, UK. p.o.d.pharoah@liv.ac.uk

Acta Paediatrica (Oslo, Norway : 1992). Supplement
|May 3, 2001
PubMed
Summary

Identical twins face higher risks of fetal or infant death compared to fraternal twins. Undiagnosed twin deaths may contribute to apparent singleton cases of cerebral palsy and impairment.

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Area of Science:

  • Perinatology
  • Twin Gestation Studies
  • Neurology

Background:

  • Twin pregnancies present unique risks compared to singleton births.
  • Monozygous (identical) twins share a placenta, increasing risks of complications.
  • Previous research indicates higher mortality rates in twin gestations.

Purpose of the Study:

  • To compare mortality risks between monozygous and dizygous twins.
  • To determine the prevalence of cerebral palsy and impairment in survivors of co-twin fetal death.
  • To investigate the potential underdiagnosis of twin deaths in relation to cerebral palsy cases.

Main Methods:

  • National follow-up study of twin births.
  • Comparison of mortality outcomes between monozygous and dizygous twins.
  • Prevalence calculation of cerebral palsy and cerebral impairment in survivors of co-twin fetal death.

Main Results:

  • Monozygous twins had significantly higher risks for in utero death, one in utero and co-twin infant death, or both dying in infancy compared to dizygous twins.
  • Prevalence of cerebral palsy among survivors of co-twin fetal death was 80.2 per 1000.
  • Prevalence of other cerebral impairment was 107.0 per 1000 survivors.

Conclusions:

  • Twin deaths, particularly unrecognized ones, may be a significant factor in the incidence of cerebral palsy and impairment.
  • Healthcare providers should consider the possibility of a co-twin death in cases of apparent singleton cerebral palsy.
  • Improved recognition and registration of twin gestations and deaths are crucial for accurate epidemiological data.

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