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[Persistent hyperglycemia and hyperinsulinemia in a newborn infant]

L Tapia Ceballos1, J Romero Sánchez, B Picazo Angelin

  • 1Area de Pediatría, Hospital Costa del Sol. Marbella, Málaga. leotapiaceb@hotmail.com

Anales Espanoles De Pediatria
|May 3, 2001
PubMed

Insights

Neonatal hyperglycemia management is complex, often caused by iatrogeny. This case highlights Donohue syndrome (leprechaunism) as a rare cause of severe insulin resistance in newborns requiring insulin therapy.

Area of Science:

  • Neonatology
  • Endocrinology
  • Genetics

Background:

  • Neonatal hyperglycemia presents complex management challenges, particularly in preterm infants.
  • Iatrogenic causes are frequent, but rare conditions like neonatal diabetes mellitus also occur.
  • High insulin requirements ( > 2 IU/kg/day) suggest insulin resistance syndrome.

Observation:

  • A case of a newborn infant with Donohue syndrome (leprechaunism) is presented.
  • Donohue syndrome is a rare, genetically determined disorder.
  • The infant exhibited significant insulin resistance.

Findings:

  • Donohue syndrome leads to profound insulin resistance in neonates.
  • Management requires careful monitoring of insulin needs.
  • This genetic condition underscores the diverse etiologies of neonatal hyperglycemia.

Implications:

  • Recognizing rare genetic syndromes is crucial for diagnosing neonatal hyperglycemia.
  • Early identification of insulin resistance syndromes can guide appropriate treatment.
  • Understanding Donohue syndrome improves clinical approaches to complex neonatal metabolic disorders.

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