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Related Experiment Videos

Feline immunodeficiency virus cell entry.

S C Frey1, E A Hoover, J I Mullins

  • 1Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.

Journal of Virology
|May 3, 2001
PubMed
Summary
This summary is machine-generated.

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Feline immunodeficiency virus (FIV) uses the CXCR4 receptor for cell entry, not CCR5. Zidovudine effectively inhibited late viral replication, including circular DNA formation, in this CD4-independent process.

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Feline immunodeficiency virus (FIV) is an important pathogen affecting domestic cats.
  • Understanding the mechanisms of FIV cell entry is crucial for developing antiviral strategies.

Purpose of the Study:

  • To investigate the cellular receptors utilized by FIV subtype B during cell entry.
  • To evaluate the efficacy of Zidovudine in inhibiting FIV replication intermediates.

Main Methods:

  • Assays for virus replication intermediates were employed.
  • FIV subtype B infection models were utilized.

Main Results:

  • FIV subtype B was identified to use the chemokine receptor CXCR4, but not CCR5, for cellular entry.

Related Experiment Videos

  • Zidovudine demonstrated significant inhibition of late viral replication products, including circular DNA genome intermediates.

    • Conclusions:

    • CXCR4 serves as a primary cellular receptor for CD4-independent cell entry by FIV.
    • Zidovudine is a potent inhibitor of FIV replication, targeting late-stage viral DNA formation.