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Is antigen presentation the primary function of HLA-G?
1Inserm U 395, CHU Purpan, BP 3028, 31024 Toulouse cedex 3, France. phil.lb@purpan.inserm.fr
Microbes and Infection
|May 4, 2001
Abstract:
Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness.