Related Experiment Video
Updated: Aug 16, 2026

Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
Published on: January 17, 2016
Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis
K McDougall1, C Kubu, J M Verdi
1Neurodegeneration Group, The John P. Robarts Research Institute, 100 Perth Drive, London, Ontario, N6A 5K8, Canada.
Abstract:
Two fibroblast growth factor (FGF) receptor substrates (FRS2 and FRS3) are involved in downstream signaling from activated FGF receptors and neurotrophin-activated Trk receptors. Despite the importance of signaling from these factors in embryogenesis, FRS2 and FRS3 expression patterns during development are unknown. In this study we characterize the expression of FRS2 and FRS3 from E7 to parturition and in adult murine tissues. Both are first detected in whole E8.5 CD1 mouse embryos. FRS2 is detected as early as E7 in the developing syncytiotrophoblast, later in the neural tube (NT) and in many adult and fetal tissues. FRS3 is more restricted in location than FRS2 (fetal NT, heart, stomach, liver and some adult tissues), and is expressed predominantly in the ventricular layer of the developing NT and brains of murine embryos.
More Related Videos
07:34The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
Published on: February 16, 2017
14:34A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo
Published on: May 6, 2022
Related Concept Videos
Determination
Non-Canonical Wnt Signaling Pathways
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...