Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardioprotection: emerging pharmacotherapy.

R J Gumina1, A Jahangir, G J Gross

  • 1Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA.

Expert Opinion on Pharmacotherapy
|May 5, 2001
PubMed
Summary

Acute coronary occlusion is a leading cause of death. Novel cardioprotective therapies aim to limit cardiomyocyte death from ischemia/reperfusion injury, improving survival in acute coronary syndromes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence, Variants and Presentation of Anomalous Aortostial Origin of Coronary Arteries: A Registry Based Analysis of Ten Cases.

Mymensingh medical journal : MMJ·2025
Same author

Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata.

The Journal of hospital infection·2019
Same author

Presence of obesity is associated with lower mortality in elderly patients with implantable cardioverter defibrillator.

International journal of obesity (2005)·2017
Same author

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics.

Clinical pharmacology and therapeutics·2017
Same author

Affairs of the Heart: Innovation in Cardiovascular Research and Development.

Clinical pharmacology and therapeutics·2017
Same author

Clinical Pharmacology & Therapeutics: Past, Present, and Future.

Clinical pharmacology and therapeutics·2017

Area of Science:

  • Cardiovascular Medicine
  • Cellular Biology
  • Pharmacology

Background:

  • Acute coronary occlusion is a leading global cause of mortality.
  • Reperfusion therapy improves survival in acute coronary syndromes but has time limitations for myocardial salvage.
  • Cardiomyocyte susceptibility to ischemia/reperfusion injury is a key factor limiting patient survival.

Purpose of the Study:

  • To review the fundamental mechanisms of ischemia/reperfusion injury.
  • To examine novel cardioprotective mechanisms for limiting or delaying myocyte death.
  • To discuss clinical evidence for myocardial protective therapies in acute coronary syndromes.

Main Methods:

  • Review of recent scientific literature on ischemia/reperfusion injury.
  • Analysis of emerging therapeutic strategies targeting cardiomyocyte protection.

Related Experiment Videos

  • Evaluation of clinical trial data for cardioprotective agents.

    • Main Results:

    • Significant progress in understanding ischemia/reperfusion injury mechanisms.
    • Development of novel therapeutic candidates aimed at reducing myocyte death.
    • Identification of key targets for cardioprotection.

    Conclusions:

    • Cardiomyocyte protection is crucial for improving outcomes in acute coronary syndromes.
    • Emerging therapies hold promise for enhancing myocardial salvage beyond current reperfusion strategies.
    • Further clinical investigation is warranted for novel cardioprotective agents.