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Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression
1Department of Dermatology, Yamagata University School of Medicine, Yamagata, Japan. hitakeda@med.id.yamagata-u.ac.jp
The American Journal of Pathology
|May 5, 2001
Summary
Angiotensin type 1 receptor (AT1) is present in human skin epidermis and may play a role in differentiation. AT1 expression levels can help distinguish between skin squamous cell carcinoma (SCC) and keratoacanthoma (KA).
Area of Science:
- Dermatology
- Molecular Biology
- Oncology
Background:
- The role and presence of angiotensin II receptors in human skin remain largely undetermined.
- Angiotensin II receptors are key components of the renin-angiotensin system.
- Understanding skin receptor expression is crucial for dermatological research.
Purpose of the Study:
- To investigate the expression and distribution of angiotensin receptors in normal and cancerous human skin.
- To determine if angiotensin type 1 receptor (AT1) expression can differentiate between squamous cell carcinoma (SCC) and keratoacanthoma (KA).
Main Methods:
- Immunohistochemical analysis was employed to study AT1 receptor expression.
- Expression was examined in normal human suprabasal epidermis, skin SCC, lip SCC, and keratoacanthoma (KA).
Main Results:
- AT1 receptor expression was detected in the suprabasal epidermis of normal human skin, suggesting a role in differentiation.
- High, intermediate, and low levels of AT1 were observed in 50 cases of skin SCC (74.0%, 14.0%, and 4.0%, respectively).
- A negative periphery pattern of AT1 expression was noted in 77.3% of 22 KA cases, differentiating it from SCC.
Conclusions:
- Immunohistochemical detection of AT1 receptor is a potential diagnostic tool to distinguish between skin SCC and KA.
- Further research into the role and distribution of AT1 in the skin may elucidate its involvement in skin pathophysiology.