Biologically active substituted benzodiazepines and their effect on cardiovascular and central nervous system

Some substituted 1,5-benzodiazepine derivatives (including a spirocyclopentane moiety) were synthesized (Table I) and evaluated for their hypotensive and CNS activities respectively. The compounds which showed promising cardiovascular activity also exhibited marked anti-depressant action (Table II,III,IV). All the compounds showed higher ALD50 value.