Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electronic field effect detection of SARS-CoV-2 N-protein before the onset of symptoms.

Biosensors & bioelectronics·2022
Same author

An ultrasensitive heart-failure BNP biosensor using B/N co-doped graphene oxide gel FET.

Biosensors & bioelectronics·2021
Same author

The role of the nephrologist in ESRD/Pre-ESRD care: a collaborative approach.

Journal of the American Society of Nephrology : JASN·2001
Same author

ACE inhibition or angiotensin receptor blockade: impact on potassium in renal failure. VAL-K Study Group.

Kidney international·2000
Same author

Intravenous iron dextran treatment in predialysis patients with chronic renal failure.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2000
Same author

Treatment of glomerular diseases: ANCA-negative RPGN.

Seminars in nephrology·2000

Related Experiment Video

Updated: Jul 10, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Pathogenesis of focal glomerulosclerosis.

W K Bolton1, E Abdel-Rahman

  • 1Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908, USA. wkb5s@virginia.edu

Nephron
|May 8, 2001
PubMed
Summary

Focal segmental glomerulosclerosis (FSGS) involves diverse causes and complex factors influencing its varied clinical presentations. Understanding these elements is crucial for developing targeted therapies to slow disease progression.

Area of Science:

  • Nephrology
  • Renal Pathology
  • Glomerular Diseases

Background:

  • Focal segmental glomerulosclerosis (FSGS) is a kidney disease characterized by scarring in glomeruli.
  • FSGS presents in primary and secondary forms, each with distinct etiologies and pathogenic factors.
  • The disease exhibits a wide spectrum of clinical manifestations, from mild proteinuria to rapid kidney failure.

Purpose of the Study:

  • To elucidate the complex interplay of factors contributing to FSGS development and progression.
  • To highlight the role of genetic predisposition, environmental influences, and pharmacologic interventions.
  • To underscore the need for understanding pathogenesis to guide therapeutic strategies.

Main Methods:

  • Review and synthesis of existing knowledge on FSGS pathogenesis.

More Related Videos

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Related Experiment Videos

Last Updated: Jul 10, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

  • Analysis of contributing factors in both primary and secondary FSGS.
  • Examination of the impact of various influences on FSGS phenotype.

    • Main Results:

    • Identified numerous pathogenic factors in primary FSGS and defined etiologies for secondary FSGS.
    • Demonstrated a complex interaction between etiologic, pathogenic, and progression factors.
    • Highlighted the influence of genetic and environmental factors, as well as drug interventions, on FSGS phenotype.

    Conclusions:

    • While the precise pathogenesis of FSGS remains unknown, significant knowledge exists regarding contributing factors.
    • A comprehensive understanding of these factors is essential for clinicians to manage FSGS effectively.
    • The ultimate goal is to develop specific, non-toxic therapies for identifiable forms of FSGS.