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Related Experiment Videos

Innexins get into the gap.

P Phelan1, T A Starich

  • 1Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK. P.Phelan@ukc.ac.uk

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|May 8, 2001
PubMed
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Connexins form vertebrate gap junctions, and mutations cause human diseases. A second family, innexins, forms channels in invertebrates like flies and worms, aiding genetic gap junction studies.

Area of Science:

  • Cell biology
  • Molecular biology
  • Genetics

Background:

  • Connexins, identified in the 1970s, are the primary molecular components of vertebrate gap junctions.
  • A significant body of research exists on connexin cell and molecular biology, linking mutations to various human diseases.
  • For years, "connexin" and "gap junction" were used almost interchangeably.

Purpose of the Study:

  • To introduce the innexin gene family as a second class of gap junction-forming proteins.
  • To highlight the discovery and characterization of innexins in invertebrate model organisms.
  • To emphasize the utility of completed genomic sequences for studying gap junction function.

Main Methods:

  • Literature review and synthesis of existing research on connexins and innexins.

Related Experiment Videos

  • Identification of innexin genes in completed genomic sequences of Drosophila melanogaster and Caenorhabditis elegans.
  • Comparative analysis of connexin and innexin roles in intercellular communication.

    • Main Results:

    • Connexins are established as vertebrate gap junction components linked to disease.
    • Innexins represent a distinct family of gap junction genes found in invertebrates.
    • Genomic data for Drosophila and C. elegans facilitate comprehensive innexin gene identification.

    Conclusions:

    • Innexins provide a new avenue for studying gap junction biology, particularly in genetically tractable invertebrates.
    • The identification of innexin genes offers valuable resources for future genetic analyses of gap junction function.
    • Understanding both connexins and innexins is crucial for a complete picture of intercellular communication.