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Exploring the domain structure of modular nonribosomal peptide synthetases
1Biochemie/Fachbereich Chemie, Philipps-Universität, 35032 Marburg, Germany.
Structure (London, England : 1993)
|May 9, 2001
Abstract:
Recently, considerable insight has been gained into the modular organization of nonribosomal peptide synthetases (NRPS). The three-dimensional structures of domains associated with substrate adenylation and covalent binding have been solved as well as the structure of a priming enzyme required for the post-translational modification of NRPS. Taken together, these studies will help us to understand the architecture of these mega-enzymes.