Adaptive changes in delta 9 desaturase activity in rat liver

The delta 9 desaturase activity and the 14-C radioactivity of the de novo synthesized fatty acids incorporated into microsomal lipids and serum triglycerides were measured under different nutritional conditions. The results obtained indicate a correlation between the values of the three parameters studied after starvation or after refeeding Purina chow or either a high carbohydrate or a high protein diet. These data suggest that liver lipogenesis and delta 9 desaturase activities respond to the same regulatory factors.