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High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection

B J Van Lenten1, A C Wagner, D P Nayak

  • 1Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA. bvanlent@mednet.ucla.edu

Circulation
|May 23, 2001
PubMed
Abstract

Insights

Influenza infection alters high-density lipoprotein (HDL) composition, reducing its anti-inflammatory capacity. This study investigated changes in HDL during acute influenza in mice.

Area of Science:

  • Cardiovascular Science
  • Virology
  • Immunology

Background:

  • Viruses are implicated in the development of atherosclerosis.
  • Influenza A virus infection serves as a model to study viral impact on cardiovascular health.

Purpose of the Study:

  • To investigate the effects of acute influenza infection on high-density lipoprotein (HDL) functionality.
  • To determine how influenza impacts HDL's anti-atherogenic properties.

Main Methods:

  • C57BL/6J mice were infected intranasally with Influenza A strain WSN/33.
  • Analysis of HDL components (paraoxonase, platelet-activating factor acetylhydrolase, apoA-I, apoJ, ceruloplasmin) and functionality (inhibition of LDL oxidation, monocyte chemotaxis) at various time points post-infection.
  • Measurement of plasma inflammatory markers (interleukin-6, serum amyloid A).

Main Results:

  • Influenza infection led to decreased activities of paraoxonase and platelet-activating factor acetylhydrolase in HDL.
  • HDL's ability to inhibit LDL oxidation and monocyte chemotaxis was reduced post-infection.
  • Plasma levels of interleukin-6 and serum amyloid A increased, indicating an inflammatory response.

Conclusions:

  • Acute influenza infection alters HDL composition, specifically affecting paraoxonase, platelet-activating factor acetylhydrolase, ceruloplasmin, and apoJ levels.
  • These HDL alterations result in a loss of its anti-inflammatory properties.
  • Influenza-induced changes in HDL may contribute to atherogenesis.

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