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MDMA-assisted brief cognitive behavioral conjoint therapy for PTSD: Study protocol for a pilot study.

L A Morland1,2,3, D Perivoliotis2,3, T R Wachsman2

  • 1Department of Veterans Affairs National Center for PTSD Women's Health Sciences Division, 150 South Huntington Street, Boston, MA, 02130, USA.

Contemporary Clinical Trials Communications
|July 12, 2024
PubMed
Summary
This summary is machine-generated.

This study explores MDMA-assisted therapy combined with brief Cognitive-Behavioral Conjoint Therapy (bCBCT) to improve relationship functioning for veterans with Posttraumatic Stress Disorder (PTSD). The research aims to enhance treatment outcomes for both veterans and their partners.

Keywords:
Brief cognitive-behavioral conjoint therapyIntimate relationshipsMDMAPTSD

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Area of Science:

  • Psychiatry
  • Psychology
  • Clinical Research

Background:

  • Posttraumatic Stress Disorder (PTSD) significantly affects individual and relational well-being, particularly in veteran couples facing military stressors.
  • While brief Cognitive-Behavioral Conjoint Therapy (bCBCT) effectively reduces PTSD symptoms, its impact on relationship functioning is variable.
  • Improving relational outcomes in PTSD treatment is crucial for veterans' overall health, with MDMA-assisted therapy showing potential to augment existing interventions like bCBCT.

Purpose of the Study:

  • To assess the preliminary efficacy, safety, and acceptability of combining MDMA-assisted therapy with bCBCT for veterans with PTSD and their partners.
  • To investigate the potential of this combined approach to improve both PTSD symptom severity and relationship functioning.
  • To pilot a scalable treatment model within the Veterans Affairs healthcare system.

Main Methods:

  • An open-label, single-site study involving 8 veterans with PTSD and their intimate partners (N=16).
  • Therapy teams delivered bCBCT integrated with two MDMA-assisted therapy sessions.
  • Two couple emotion-focused integration sessions were conducted post-MDMA, with evaluations of PTSD symptoms and relationship functioning.

Main Results:

  • Preliminary data on the efficacy, safety, and acceptability of MDMA-assisted bCBCT will be gathered.
  • The study will provide initial insights into the impact on PTSD symptom severity.
  • Changes in relationship functioning outcomes will be evaluated.

Conclusions:

  • This is the first study to investigate MDMA-assisted bCBCT for improving PTSD and relationship functioning in U.S. military veterans and their partners.
  • The findings could inform a scalable model for treating PTSD within the VA healthcare system.
  • This approach may offer downstream benefits for partners, enhancing individual and relationship functioning.