Related Experiment Video

Updated: Jun 29, 2025

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.3K

Severity of COVID-19 manifestations in HIV patients: a systematic review and meta-analysis

A Alam1, A A Soeroto, R A Susilohadi

  • 1Infectious and Tropical Diseases Division, Department of Child Health, Universitas Padjadjaran-Hasan Sadikin General Hospital, Bandung, Indonesia. anggraini.alam@unpad.ac.id.

European Review for Medical and Pharmacological Sciences
|April 3, 2024
PubMed

Insights

People living with HIV (PLWH) and HIV-negative individuals experienced similar COVID-19 rates and severity. Antiretroviral therapy (ART) is crucial for managing COVID-19 in PLWH, maintaining immunological health.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Public Health

Background:

  • The COVID-19 pandemic poses increased risks for people living with HIV (PLWH) due to potential immune compromise.
  • Antiretroviral therapy (ART) may offer protective benefits against severe COVID-19 outcomes in PLWH.

Approach:

  • A systematic review adhering to PRISMA guidelines was conducted, analyzing English-language articles from 2019-2022.
  • Literature from PubMed, Science Direct, and Cochrane Library was screened for studies reporting HIV and COVID-19 case prevalence by severity.
  • A random-effects model was employed to determine the pooled prevalence and severity of COVID-19 among PLWH.

Key Points:

  • The study included 13 articles from an initial 1,965, analyzing COVID-19 prevalence and severity in PLWH.
  • Pooled COVID-19 prevalence among PLWH was 3.0%, with critical, moderate, and mild severity rates of 4.8%, 24.4%, and 9.9%, respectively.
  • Demographics showed a mean age of 52.98 years for PLWH with COVID-19, with 73% being male.

Conclusions:

  • COVID-19 incidence and severity were comparable between PLWH and HIV-negative individuals.
  • ART effectively supports immunological health in PLWH, comparable to immunocompetent individuals.
  • ART plays a vital role in mitigating COVID-19 severity and mortality among PLWH.
Abstract

More Related Videos

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

31.6K

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
242
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
269
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
306
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.9K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K