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Bladder dysfunction after acute urinary retention in rats
1Department of Urology, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
The Journal of Urology
|May 9, 2001
Summary
Acute urinary retention and catheterization impair rat bladder function. Free radicals contribute to this dysfunction, impacting bladder contractility and blood flow.
Area of Science:
- Urology
- Physiology
- Biochemistry
Background:
- Acute urinary retention (AUR) can lead to bladder dysfunction.
- Catheterization is a common procedure following AUR.
- The underlying mechanisms of post-catheterization bladder dysfunction require further investigation.
Purpose of the Study:
- To investigate the effects of acute urinary retention and subsequent catheterization on rat bladder function.
- To explore the role of free radicals in bladder dysfunction during AUR and after catheterization.
Main Methods:
- Acute urinary retention was induced in rats by urethral clamping and saline infusion.
- Bladder contractile responses to carbachol were measured.
- In vivo monitoring of bladder blood flow and vesical pressure was performed.
- Levels of malonaldehyde and 4-hydroxyalkenals were quantified.
Main Results:
- Acute urinary retention decreased bladder blood flow and increased vesical pressure.
- Catheterization led to reduced bladder contractility and altered blood flow/pressure dynamics.
- Concentrations of malonaldehyde and 4-hydroxyalkenals were significantly elevated post-catheterization.
Conclusions:
- Bladder dysfunction following catheterization is partly mediated by free radical damage.
- Free radicals play a significant role in the pathophysiology of acute urinary retention-induced bladder dysfunction.