Related Experiment Video
Updated: Aug 18, 2026

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
Published on: May 4, 2020
Nanoscale biogenic iron oxides and neurodegenerative disease
1Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Thornburrow Drive, Hartshill, Stroke-on-Trent ST4 7QB, UK. jdobson@keele.ac.uk
Abstract:
One of the characteristics of many neurodegenerative diseases is the disruption of normal iron homeostasis in the brain. Recent experimental work indicates that nanoscale magnetic biominerals (primarily magnetite and maghemite) may be associated with senile plaques and tau filaments found in brain tissue affected by these diseases. These findings have important implications for our understanding of the role of iron in neurodegenerative disease as well as profound implications for their causes. In addition, the presence of biogenic magnetite in affected tissue should also provide improved mechanisms for early detection through the modification of MRI pulse sequences.
Related Concept Videos
Neural Regulation
Alzheimer Disease ll: Pathophysiology

