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Receptor clustering and transmembrane signaling in T cells
J R Cochran1, D Aivazian, T O Cameron
1Dept of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Trends in Biochemical Sciences
|May 10, 2001
Abstract:
T cells are activated via engagement of their cell-surface receptors with molecules of the major histocompatibility complex (MHC) displayed on another cell surface. This process, which is a key step in the recognition of foreign antigens by the immune system, involves oligomerization of receptor components. Recent characterization of the T-cell response to soluble arrays of MHC-peptide complexes has provided insights into the triggering mechanism for T-cell activation.